Standard Name	ARO1
Systematic Name	YDR127W
Feature Type	ORF, Verified
Description	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids (1, 2)
Name Description	AROmatic amino acid requiring

Chromosomal Location	ChrIV:704484 to 709250 | ORF Map | GBrowse
	Genetic position: 81 cM

	View Computational GO annotations for ARO1
Molecular Function
Manually curated	3-dehydroquinate dehydratase activity (IDA) 3-dehydroquinate synthase activity (IDA) 3-phosphoshikimate 1-carboxyvinyltransferase activity (IDA) shikimate 3-dehydrogenase (NADP+) activity (IDA) shikimate kinase activity (IDA)
Biological Process
Manually curated	chorismate biosynthetic process (TAS)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	chorismate biosynthesis pathways of chorismate superpathway of phenylalanine, tyrosine and tryptophan biosynthesis

Classical genetics
null	tellurium atom accumulation: decreased resistance to 2-phenylethanol: decreased
Large-scale survey
null	alkaline pH resistance: decreased polyphosphate accumulation: abnormal competitive fitness: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to 4-chlorophenol: decreased resistance to methyl methanesulfonate: decreased resistance to hydrogen chloride: decreased resistance to acetic acid: decreased resistance to (S)-lactic acid: decreased resistance to tunicamycin: decreased resistance to propan-1-ol: decreased resistance to ethanol: decreased resistance to sulfanilamide: decreased resistance to miconazole: decreased resistance to mycophenolic acid: increased resistance to bleomycin: increased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to 2,4-dichlorophenol: decreased resistance to pentachlorophenol: decreased resistance to camptothecin: decreased resistance to acrolein: decreased resistance to sorbate: decreased toxin resistance: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	467 total interaction(s) for 343 unique genes/features.
Physical Interactions	Affinity Capture-MS: 58 Affinity Capture-RNA: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 318 Positive Genetic: 77 Synthetic Growth Defect: 6 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:704484 to 709250 | ORF Map | GBrowse
	Genetic position: 81 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4767 704484..709250 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002534