Standard Name	DPB4 1
Systematic Name	YDR121W
Feature Type	ORF, Verified
Description	Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization (1, 2, 3, 4, 5, 6)
Name Description	DNA Polymerase B (II) subunit

Chromosomal Location	ChrIV:693585 to 694175 | ORF Map | GBrowse

	View Computational GO annotations for DPB4
Molecular Function
Manually curated	chromatin DNA binding (IDA) contributes_to DNA-directed DNA polymerase activity (IDA, IMP, IPI) contributes_to double-stranded DNA binding (IDA) nucleosomal DNA binding (IDA) contributes_to single-stranded DNA binding (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) DNA-dependent DNA replication (IDA, IMP) error-prone translesion synthesis (IDA) heterochromatin organization involved in chromatin silencing (IGI, IMP) leading strand elongation (IGI, IMP) nucleosome mobilization (IDA) replicative senescence (IMP)
Cellular Component
Manually curated	CHRAC (IDA, IPI) epsilon DNA polymerase complex (IDA, IPI)

Classical genetics
null	cell cycle progression in S phase: increased duration heat sensitivity: increased mating efficiency: decreased resistance to 4-aminofolic acid and sulfanilamide: decreased vegetative growth: decreased rate viable
Large-scale survey
null	anaerobic growth: decreased budding index: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased lifespan: increased resistance to fluconazole: increased resistance to tunicamycin: increased resistance to ethanol: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to camptothecin: decreased resistance to BPS: increased starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	190 total interaction(s) for 93 unique genes/features.
Physical Interactions	Affinity Capture-MS: 42 Affinity Capture-RNA: 1 Affinity Capture-Western: 13 Co-fractionation: 1 Co-purification: 4 Reconstituted Complex: 4 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 65 Phenotypic Enhancement: 20 Phenotypic Suppression: 11 Positive Genetic: 6 Synthetic Growth Defect: 11 Synthetic Lethality: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:693585 to 694175 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..591 693585..694175 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002528