RLI1/YDR091C Summary

RLI1 BASIC INFORMATION

Standard Name	RLI1 1
Systematic Name	YDR091C
Feature Type	ORF, Verified
Description	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase (2, 3)
Name Description	RNase L Inhibitor

GO Annotations	All RLI1 GO evidence and references
	View Computational GO annotations for RLI1
Molecular Function
Manually curated	ATPase activity (ISS) iron ion binding (IDA)
Biological Process
Manually curated	ribosomal large subunit biogenesis (IMP) ribosomal subunit export from nucleus (IMP) translational initiation (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) cytosolic ribosome (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All RLI1 Phenotype details and references
Classical genetics
overexpression	resistance to nocodazole: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
overexpression	cell cycle progression: abnormal inviable

Interactions	RLI1 All interactions details and references
	109 total interaction(s) for 91 unique genes/features.
Physical Interactions	Affinity Capture-MS: 60 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 2 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 14 Phenotypic Suppression: 28

Sequence Information

ChrIV:628532 to 626706 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1827	628532..626706	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002498

RLI1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RLI1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RLI1]

1)	Rutkowski, L.H. and R.E. Esposito (1999) personal communication
2)	Dong J, et al. (2004) The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem 279(40):42157-68
3)	Kispal G, et al. (2005) Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J 24(3):589-98

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