UBC5/YDR059C Summary 
| Standard Name | UBC5 |
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| Systematic Name | YDR059C |
| Feature Type | ORF, Verified |
| Description | Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication (1, 2, 3, 4, 5 and see Summary Paragraph) |
| Name Description | UBiquitin-Conjugating |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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Gene Ontology Annotations All UBC5 GO evidence and references
| View Computational GO annotations for UBC5 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Mutant phenotypes All UBC5 Phenotype evidence and references
interactions All UBC5 Interaction evidence and references
| 51 total interaction(s) for 29 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All UBC5 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||||||||||||
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000002466 |
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SUMMARY PARAGRAPH for UBC5
UBC5 encodes a ubiquitin conjugating enzyme that links ubiquitin (Ubi4p) to lysine residues of target proteins (1, 6). Ubc5p plays a role in protein polyubiquitination (1), acts as a central component of the cellular stress response (2) and is also involved in sporulation (6). Ubc5p is associated with the proteasome complex (7). A related ubiquitin conjugating enzyme, (UBC4), shows strong sequence similarity to UBC5 and both are complementary in function (1). Together, Ubc5p and Ubc4p mediate the selective degradation of short-lived and abnormal proteins. Loss of UBC4 and UBC5 results in cell growth defects, temperature sensitivity, inviability in the presence of an amino acid analog, and the induction of the stress response (1).
Last updated: 2005-05-24 
References cited on this page View Complete Literature Guide for UBC5
| 1) | Seufert W and Jentsch S (1990) Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. EMBO J 9(2):543-50 |
| 2) | Seufert W and Jentsch S (1991) Yeast ubiquitin-conjugating enzymes involved in selective protein degradation are essential for cell viability. Acta Biol Hung 42(1-3):27-37 |
| 3) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 4) | Singh RK, et al. (2009) Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis. Nat Cell Biol 11(8):925-33 |
| 5) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 6) | Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39 |
| 7) | Tongaonkar P, et al. (2000) Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome. Mol Cell Biol 20(13):4691-8 |
