Standard Name	LYS14 1
Systematic Name	YDR034C
Feature Type	ORF, Verified
Description	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer (2, 3, 4, 5)
Name Description	LYSine requiring

Chromosomal Location	ChrIV:512109 to 509737 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 8 cM

	View Computational GO annotations for LYS14
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (ISA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine (IMP) positive regulation of transcription from RNA polymerase II promoter (IDA, IMP)
Cellular Component
Manually curated	nucleus (IDA)

Binding motifs	AAATTCCG 6 [Search intergenic regions for AAATTCCG] AATTCCGB 7 [Search intergenic regions for AATTCCGB]
Regulatory modules	predicted: cellcycle (263)
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
reduction of function	thermotolerance: increased
Large-scale survey
null	competitive fitness: decreased resistance to selenomethionine: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	19 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 11 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:512109 to 509737 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 8 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2373 512109..509737 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002441