VPS54/YDR027C Summary Help

VPS54 BASIC INFORMATION

Standard Name VPS54 1
Systematic Name YDR027C
Alias LUV1 , CGP1 , TCS3
Feature Type ORF, Verified
Description Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p (2, 3)
Name Description Vacuolar Protein Sorting
GO Annotations All VPS54 GO evidence and references
    View Computational GO annotations for VPS54
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All VPS54 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions VPS54 All interactions details and references
57 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-Western: 19
  • Biochemical Activity: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 8
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 2
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 8
Sequence Information
ChrIV:497316 to 494647 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2670 497316..494647 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002434

VPS54 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for VPS54

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VPS54]

1) Conibear E and Stevens TH  (2000) Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. Mol Biol Cell 11(1):305-23
2) Conibear E, et al.  (2003) Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p. Mol Biol Cell 14(4):1610-23
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64