Standard Name	LRG1
Systematic Name	YDL240W
Feature Type	ORF, Verified
Description	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis (1)
Name Description	Lim-RhoGap homolog 2

Chromosomal Location	ChrIV:22823 to 25876 | ORF Map | GBrowse

	View Computational GO annotations for LRG1
Molecular Function
Manually curated	Rho GTPase activator activity (IDA)
Biological Process
Manually curated	fungal-type cell wall biogenesis (IGI) small GTPase mediated signal transduction (IC, IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) site of polarized growth (IDA)
High-throughput	cellular bud neck (IDA) cytoplasm (IDA) mitochondrion (IDA)

Classical genetics
null	invasive growth: increased mating efficiency: decreased necrotic cell death: decreased viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to amitrole: decreased resistance to (S)-lactic acid: increased resistance to cycloheximide: decreased starvation resistance: decreased viable
overexpression	resistance to sirolimus: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	66 total interaction(s) for 52 unique genes/features.
Physical Interactions	Biochemical Activity: 1 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 5 Negative Genetic: 23 Phenotypic Enhancement: 5 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Lethality: 1 Synthetic Rescue: 15
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:22823 to 25876 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3054 22823..25876 1996-07-31 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002399