YPD1/YDL235C Summary Help

Standard Name YPD1
Systematic Name YDL235C
Feature Type ORF, Verified
Description Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus (1, 2, 3, 4)
Name Description tyrosine (Y) Phosphatase Dependent
Chromosomal Location
ChrIV:33918 to 33415 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All YPD1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
reduction of function
Large-scale survey
null
reduction of function
unspecified
Resources
124 total interaction(s) for 88 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 13
  • Co-crystal Structure: 3
  • PCA: 7
  • Reconstituted Complex: 4
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 24
  • Positive Genetic: 50
  • Synthetic Lethality: 3
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 167
Molecular Weight (Da) 19,168
Isoelectric Point (pI) 4.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:33918 to 33415 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..504 33918..33415 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002394
References cited on this page View Complete Literature Guide for YPD1
1) Janiak-Spens F and West AH  (2000) Functional roles of conserved amino acid residues surrounding the phosphorylatable histidine of the yeast phosphorelay protein YPD1. Mol Microbiol 37(1):136-44
2) Lu JM, et al.  (2003) Saccharomyces cerevisiae histidine phosphotransferase Ypd1p shuttles between the nucleus and cytoplasm for SLN1-dependent phosphorylation of Ssk1p and Skn7p. Eukaryot Cell 2(6):1304-14
3) Hohmann S  (2009) Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae. FEBS Lett 583(24):4025-9
4) Rodriguez-Pena JM, et al.  (2010) The high-osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routes. Yeast 27(8):495-502