RRI1/YDL216C Summary Help

Standard Name RRI1 1
Systematic Name YDL216C
Alias CSN5 , JAB1
Feature Type ORF, Verified
Description Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling (2, 3, 4)
Name Description Regulator of Rub1 specific Isopeptidase
Chromosomal Location
ChrIV:70319 to 68997 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RRI1 GO evidence and references
  View Computational GO annotations for RRI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
147 total interaction(s) for 109 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 91
  • Phenotypic Suppression: 1
  • Positive Genetic: 18
  • Synthetic Growth Defect: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 440
Molecular Weight (Da) 50,811
Isoelectric Point (pI) 5.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:70319 to 68997 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2006-04-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1323 70319..68997 2011-02-03 2006-04-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002375
References cited on this page View Complete Literature Guide for RRI1
1) Lyapina S, et al.  (2001) Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292(5520):1382-5
2) Cope GA, et al.  (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298(5593):608-11
3) Wee S, et al.  (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genet 3():15
4) Maytal-Kivity V, et al.  (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21