NHP2/YDL208W Summary Help

Standard Name NHP2 1
Systematic Name YDL208W
Feature Type ORF, Verified
Description Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing (1, 2)
Name Description Non-Histone Protein 1
Chromosomal Location
ChrIV:87512 to 87982 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NHP2 GO evidence and references
  View Computational GO annotations for NHP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
repressible
Large-scale survey
conditional
null
reduction of function
Resources
105 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 62
  • Affinity Capture-RNA: 6
  • Affinity Capture-Western: 10
  • Co-purification: 1
  • PCA: 8
  • Reconstituted Complex: 7
  • Two-hybrid: 5

Genetic Interactions
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 156
Molecular Weight (Da) 17,122
Isoelectric Point (pI) 10.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:87512 to 87982 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-11-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..471 87512..87982 2011-02-03 2005-11-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002367
References cited on this page View Complete Literature Guide for NHP2
1) Kolodrubetz D and Burgum A  (1991) Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae. Yeast 7(2):79-90
2) Henras A, et al.  (1998) Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. EMBO J 17(23):7078-90