YDL183C Summary

YDL183C Summary

Reserved Name	MKR1 1 This name is reserved with SGD according to the Gene Naming Guidelines agreed upon by the yeast community. For more information about this reservation, please see the Locus History.
Systematic Name	YDL183C
Feature Type	ORF, Verified
Description	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene (2, 3, 4)
Name Description	Mitochondrial K+/H+ exchange Related 1

Chromosomal Location	ChrIV:131833 to 130871 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

Gene Ontology Annotations All YDL183C GO evidence and references


Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	potassium ion transport (IGI) proton transport (IGI)
Cellular Component
Manually curated	integral to mitochondrial inner membrane (IDA)

Mutant phenotypes All YDL183C Phenotype evidence and references

Classical genetics
null	viable
overexpression	cell cycle progression in G1 phase: abnormal
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased dessication resistance: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to ciclopirox olamine: decreased resistance to sirolimus: decreased resistance to streptomycin: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal vegetative growth: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All YDL183C Interaction evidence and references

	28 total interaction(s) for 27 unique genes/features.
Physical Interactions	Reconstituted Complex: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 16 Positive Genetic: 4 Synthetic Growth Defect: 1 Synthetic Rescue: 2
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All YDL183C Protein evidence and references

Localization	YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| AspGD Homologs \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrIV:131833 to 130871 | |

Note: this feature is encoded on the Crick strand.

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..963	131833..130871	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000002342

References cited on this page View Complete Literature Guide for

1)	Sponder G and Nowikovsky K (2010) Novel Components of an Active Mitochondrial K+/H+ Exchange J Biol Chem 285():14399-14414
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3)	Volckaert G, et al. (2003) Disruption of 12 ORFs located on chromosomes IV, VII and XIV of Saccharomyces cerevisiae reveals two essential genes. Yeast 20(1):79-88
4)	Zotova L, et al. (2010) Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem 285(19):14399-414