CRD1/YDL142C Summary Help

Standard Name CRD1 1
Systematic Name YDL142C
Alias CLS1 2 , 3
Feature Type ORF, Verified
Description Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis (1, 4, 5, 6, 7, 8)
Name Description CaRDiolipin synthase 1
Chromosomal Location
ChrIV:202570 to 201719 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All CRD1 GO evidence and references
  View Computational GO annotations for CRD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Regulators 4 genes
Classical genetics
Large-scale survey
160 total interaction(s) for 129 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 104
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 4
  • Positive Genetic: 13
  • Synthetic Growth Defect: 28
  • Synthetic Lethality: 5

Expression Summary
Length (a.a.) 283
Molecular Weight (Da) 32,019
Isoelectric Point (pI) 10.55
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:202570 to 201719 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..852 202570..201719 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002301
References cited on this page View Complete Literature Guide for CRD1
1) Jiang F, et al.  (1999) Cardiolipin synthase expression is essential for growth at elevated temperature and is regulated by factors affecting mitochondrial development. Mol Microbiol 31(1):373-9
2) Jiang F, et al.  (1997) Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non-fermentable carbon sources. Mol Microbiol 26(3):481-91
3) Tuller G, et al.  (1998) YDL142c encodes cardiolipin synthase (Cls1p) and is non-essential for aerobic growth of Saccharomyces cerevisiae. FEBS Lett 421(1):15-8
4) Chang SC, et al.  (1998) Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae. J Biol Chem 273(24):14933-41
5) Jiang F, et al.  (2000) Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem 275(29):22387-94
6) Zhang M, et al.  (2003) Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperatures. J Biol Chem 278(37):35204-10
7) Chen S, et al.  (2008) Cardiolipin mediates cross-talk between mitochondria and the vacuole. Mol Biol Cell 19(12):5047-58
8) Joshi AS, et al.  (2012) Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae. J Biol Chem 287(21):17589-97