CRD1/YDL142C Summary Help

Standard Name CRD1 1 (see Nomenclature conflict Note)
Systematic Name YDL142C
Alias CLS1 2 , 3
Feature Type ORF, Verified
Description Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis (1, 4, 5, 6, 7)
Name Description CaRDiolipin synthase 1
Chromosomal Location
ChrIV:202570 to 201719 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CRD1 GO evidence and references
  View Computational GO annotations for CRD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Pathways
Mutant phenotypes All CRD1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All CRD1 Interaction evidence and references
144 total interaction(s) for 118 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
Genetic Interactions
  • Negative Genetic: 91
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 4
  • Positive Genetic: 12
  • Synthetic Growth Defect: 27
  • Synthetic Lethality: 5
Resources
Expression Summary
histogram
Resources
Protein Information All CRD1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:202570 to 201719 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..852 202570..201719 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002301

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
CLS1Nomenclature conflictCLS1 has been used in the literature to refer to both CRD1/YDL142C which encodes a cardiolipin synthase, and the genetic locus CLS1.
References cited on this page View Complete Literature Guide for CRD1
1) Jiang F, et al.  (1999) Cardiolipin synthase expression is essential for growth at elevated temperature and is regulated by factors affecting mitochondrial development. Mol Microbiol 31(1):373-9
2) Jiang F, et al.  (1997) Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non-fermentable carbon sources. Mol Microbiol 26(3):481-91
3) Tuller G, et al.  (1998) YDL142c encodes cardiolipin synthase (Cls1p) and is non-essential for aerobic growth of Saccharomyces cerevisiae. FEBS Lett 421(1):15-8
4) Chang SC, et al.  (1998) Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae. J Biol Chem 273(24):14933-41
5) Jiang F, et al.  (2000) Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem 275(29):22387-94
6) Zhang M, et al.  (2003) Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperatures. J Biol Chem 278(37):35204-10
7) Chen S, et al.  (2008) Cardiolipin mediates cross-talk between mitochondria and the vacuole. Mol Biol Cell 19(12):5047-58