POL3/YDL102W Summary Help

Standard Name POL3 1
Systematic Name YDL102W
Alias HPR6 , TEX1 2 , CDC2 3
Feature Type ORF, Verified
Description Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) (4)
Name Description POLymerase 1
Chromosomal Location
ChrIV:276872 to 280165 | ORF Map | GBrowse
Gbrowse
Genetic position: -55 cM
Gene Ontology Annotations All POL3 GO evidence and references
  View Computational GO annotations for POL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
dominant negative
reduction of function
unspecified
Large-scale survey
conditional
null
reduction of function
Resources
302 total interaction(s) for 172 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-Western: 4
  • Biochemical Activity: 1
  • Co-purification: 2
  • Reconstituted Complex: 5
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 5
  • Dosage Rescue: 4
  • Negative Genetic: 100
  • Phenotypic Enhancement: 26
  • Phenotypic Suppression: 16
  • Positive Genetic: 9
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 90
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,097
Molecular Weight (Da) 124,618
Isoelectric Point (pI) 8.09
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:276872 to 280165 | ORF Map | GBrowse
SGD ORF map
Genetic position: -55 cM
Last Update Coordinates: 2004-02-11 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3294 276872..280165 2004-02-11 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002260
References cited on this page View Complete Literature Guide for POL3
1) Burgers PM, et al.  (1990) Revised nomenclature for eukaryotic DNA polymerases. Eur J Biochem 191(3):617-8
2) Delgado MA, et al.  (1982) Genetic and biochemical study of threonine-overproducing mutants of Saccharomyces cerevisiae. Mol Cell Biol 2(7):731-6
3) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
4) Chanet R and Heude M  (2003) Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet 43(5):337-50