POL3/YDL102W Summary Help

Standard Name POL3 1 (see Nomenclature conflict Note)
Systematic Name YDL102W
Alias HPR6 , TEX1 2 , CDC2 3
Feature Type ORF, Verified
Description Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) (4)
Name Description POLymerase 1
Chromosomal Location
ChrIV:276872 to 280165 | ORF Map | GBrowse
Gbrowse
Genetic position: -55 cM
Gene Ontology Annotations All POL3 GO evidence and references
  View Computational GO annotations for POL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All POL3 Phenotype evidence and references
Classical genetics
conditional
reduction of function
unspecified
Large-scale survey
conditional
null
reduction of function
Resources
interactions All POL3 Interaction evidence and references
293 total interaction(s) for 172 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Co-purification: 2
  • Reconstituted Complex: 5
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 5
  • Dosage Rescue: 4
  • Negative Genetic: 99
  • Phenotypic Enhancement: 24
  • Phenotypic Suppression: 14
  • Positive Genetic: 10
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 89
  • Synthetic Rescue: 8
Resources
Expression Summary
histogram
Resources
Protein Information All POL3 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:276872 to 280165 | ORF Map | GBrowse
SGD ORF map
Genetic position: -55 cM
Last Update Coordinates: 2004-02-11 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3294 276872..280165 2004-02-11 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002260

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
CDC28Nomenclature conflictCDC28/YBR160W encodes the catalytic subunit of the main cyclin-dependent protein kinase, which is the pombe Cdc2 ortholog. Do not confuse CDC28 with the cerevisiae POL3/YDL102W gene (originally named CDC2), which encodes a subunit of DNA polymerase III.
TEX1Nomenclature conflictThe TEX1 gene name has been used by Gordenin et al., 1991 and Delgado et al., 1982 to describe POL3/YDL102W, a subunit of DNA polymerase III, and by Strasser et al., 2002 to describe TEX1/YNL253W, a component of the transcription export complex.
CDC6Nomenclature conflictCDC6/YJL194W encodes an ATPase required for DNA replication and is homologous to pombe cdc18. Do not confuse CDC6/YJL194W with the S. pombe cdc6 gene, which encodes a DNA polymerase delta subunit and is similar to the S. cerevisiae POL3/YDL102W.
References cited on this page View Complete Literature Guide for POL3
1) Burgers PM, et al.  (1990) Revised nomenclature for eukaryotic DNA polymerases. Eur J Biochem 191(3):617-8
2) Delgado MA, et al.  (1982) Genetic and biochemical study of threonine-overproducing mutants of Saccharomyces cerevisiae. Mol Cell Biol 2(7):731-6
3) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
4) Chanet R and Heude M  (2003) Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet 43(5):337-50