Standard Name	BDF2 1, 2
Systematic Name	YDL070W
Feature Type	ORF, Verified
Description	Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication (2, 3, 4)
Name Description	BromoDomain Factor 1, 2

Chromosomal Location	ChrIV:331024 to 332940 | ORF Map | GBrowse

	View Computational GO annotations for BDF2
Molecular Function
Manually curated	core promoter binding (IDA) histone acetyl-lysine binding (IDA) histone binding (IDA) TFIID-class transcription factor binding (IPI)
Biological Process
Manually curated	negative regulation of heterochromatin assembly (IGI, IMP)
Cellular Component
Manually curated	nucleus (IC)

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: decreased Rad52-YFP distribution: increased resistance to tenovin-6: decreased resistance to bleomycin: decreased resistance to benzo[a]pyrene: increased resistance to fenpropimorph: increased resistance to cycloheximide: decreased resistance to camptothecin: decreased resistance to benzo[a]pyrene: decreased resistance to mycophenolic acid: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	107 total interaction(s) for 79 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 2 Affinity Capture-Western: 3 Biochemical Activity: 22 Reconstituted Complex: 1 Two-hybrid: 12
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 36 Phenotypic Enhancement: 8 Phenotypic Suppression: 3 Positive Genetic: 2 Synthetic Growth Defect: 4 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:331024 to 332940 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1917 331024..332940 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002228