Standard Name	CBS1
Systematic Name	YDL069C
Feature Type	ORF, Verified
Description	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader (1, 2, 3)
Name Description	Cytochrome B Synthesis 4

Chromosomal Location	ChrIV:333810 to 333121 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CBS1
Molecular Function
Manually curated	translation regulator activity (IGI, IMP)
Biological Process
Manually curated	mitochondrial respiratory chain complex III biogenesis (IMP) positive regulation of mitochondrial translation (IGI, IMP)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) mitochondrial ribosome (IPI)
High-throughput	mitochondrion (IDA)

Classical genetics
null	autophagy: decreased cell cycle progression in G1 phase: increased duration critical cell size at START (G1 cell-size checkpoint): decreased replicative lifespan: increased respiratory growth: absent viable
overexpression	cell size: decreased
reduction of function	mature COB and COX1 mRNA accumulation: abnormal
Large-scale survey
null	auxotrophy cell cycle progression in G1 phase: increased duration cell size: decreased glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to elesclomol-Cu: decreased resistance to oleate: decreased respiratory growth: absent respiratory growth: decreased rate utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	11 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3
Genetic Interactions	Negative Genetic: 3 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 2 Synthetic Haploinsufficiency: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:333810 to 333121 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2004-02-11 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..690 333810..333121 2004-02-11 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002227