PTC1/YDL006W Summary Help

Standard Name PTC1 1
Systematic Name YDL006W
Alias CWH47 , KCS2 , TPD1
Feature Type ORF, Verified
Description Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation (2, 3, 4, 5, 6, 7)
Name Description Phosphatase type Two C 1
Chromosomal Location
ChrIV:439909 to 440754 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTC1 GO evidence and references
  View Computational GO annotations for PTC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All PTC1 Phenotype evidence and references
Classical genetics
null
unspecified
Large-scale survey
null
Resources
interactions All PTC1 Interaction evidence and references
616 total interaction(s) for 408 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 12
  • PCA: 18
  • Reconstituted Complex: 6
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Negative Genetic: 400
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 9
  • Positive Genetic: 81
  • Synthetic Growth Defect: 33
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 17
  • Synthetic Rescue: 5
Resources
Expression Summary
histogram
Resources
Protein Information All PTC1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:439909 to 440754 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..846 439909..440754 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002164
References cited on this page View Complete Literature Guide for PTC1
1) Maeda T, et al.  (1993) Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae. Mol Cell Biol 13(9):5408-17
2) Robinson MK, et al.  (1994) TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation. Mol Cell Biol 14(6):3634-45
3) van Zyl WH, et al.  (1989) A general screen for mutant of Saccharomyces cerevisiae deficient in tRNA biosynthesis. Genetics 123(1):55-68
4) Maeda T, et al.  (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369(6477):242-5
5) Roeder AD, et al.  (1998) Mitochondrial inheritance is delayed in Saccharomyces cerevisiae cells lacking the serine/threonine phosphatase PTC1. Mol Biol Cell 9(4):917-30
6) Warmka J, et al.  (2001) Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Mol Cell Biol 21(1):51-60
7) Malleshaiah MK, et al.  (2010) The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature 465(7294):101-5