CDC50/YCR094W Summary Help

CDC50 BASIC INFORMATION

Standard Name CDC50 1, 2
Systematic Name YCR094W
Feature Type ORF, Verified
Description Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p (2, 3, 4, 5)
Name Description Cell Division Cycle 1, 2
GO Annotations All CDC50 GO evidence and references
    View Computational GO annotations for CDC50
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CDC50 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions CDC50 All interactions details and references
48 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • PCA: 2
Genetic Interactions
  • Dosage Rescue: 10
  • Synthetic Growth Defect: 14
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 15
Sequence Information
ChrIII:286759 to 287934 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-12 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1176 286759..287934 2006-01-12 1997-01-28
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000690

CDC50 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CDC50

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC50]

1) Moir D, et al.  (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics 100(4):547-63
2) Radji M, et al.  (2001) The cloning and characterization of the CDC50 gene family in Saccharomyces cerevisiae. Yeast 18(3):195-205
3) Misu K, et al.  (2003) Cdc50p, a conserved endosomal membrane protein, controls polarized growth in Saccharomyces cerevisiae. Mol Biol Cell 14(2):730-47
4) Saito K, et al.  (2004) Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae. Mol Biol Cell 15(7):3418-32
5) Lenoir G, et al.  (2009) Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter drs2p. J Biol Chem 284(27):17956-67