CPR4/YCR069W Summary Help

Standard Name CPR4
Systematic Name YCR069W
Alias CYP4 , YCR070W , SCC3
Feature Type ORF, Verified
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog, CPR8, that arose from the whole genome duplication (1, 2, 3)
Name Description Cyclosporin-sensitive Proline Rotamase
Chromosomal Location
ChrIII:239055 to 240011 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CPR4 GO evidence and references
  View Computational GO annotations for CPR4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
8 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 318
Molecular Weight (Da) 35,780
Isoelectric Point (pI) 6.9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:239055 to 240011 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..957 239055..240011 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000665
References cited on this page View Complete Literature Guide for CPR4
1) Franco L, et al.  (1991) The nucleotide sequence of a third cyclophilin-homologous gene from Saccharomyces cerevisiae. Yeast 7(9):971-9
2) Dolinski K, et al.  (1997) All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(24):13093-8
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61