Standard Name	TAH1 1
Systematic Name	YCR060W
Feature Type	ORF, Verified
Description	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II (1, 2, 3, 4)
Name Description	Tpr-containing protein Associated with Hsp90 1

Chromosomal Location	ChrIII:224399 to 224734 | ORF Map | GBrowse

	View Computational GO annotations for TAH1
Molecular Function
Manually curated	chaperone binding (IDA, IMP, IPI)
Biological Process
Manually curated	box C/D snoRNP assembly (IMP) protein folding (IGI, IMP, IPI)
Cellular Component
Manually curated	R2TP complex (IDA, IPI)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	snR17a/b snoRNA accumulation: decreased
Large-scale survey
null	competitive fitness: increased endocytosis: decreased haploinsufficient resistance to benzo[a]pyrene: increased resistance to selenomethionine: increased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	71 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 Co-fractionation: 1 Reconstituted Complex: 9 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 17 Positive Genetic: 11 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:224399 to 224734 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..336 224399..224734 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000656