SUMMARY PARAGRAPH for RBK1
RBK1 encodes a putative ribokinase (EC: 184.108.40.206) predicted to be involved in ribose metabolism (1). Rbk1p has two regions of similarity to human ADK (OMIM), E. coli ribokinase, and the fructokinases from Kiebsiella, Salmonella, Vibrio, Rhizobium and potato, and has one region of similarity to E. coli inosine kinase and deoxygluconokinase (2, 1). Rbk1p localizes to the nucleus and cytoplasm (3).
rbk1 null mutants are viable and exhibit increased glycogen accumulation, as determined by iodine staining (4, 5). An active autonomously replicating sequence, ARS313, is located in the vicinity of RBK1 and hinders the isolation of an integrative disruption mutant (1).
Last updated: 2005-12-13