BPH1/YCR032W Summary Help

Standard Name BPH1 1
Systematic Name YCR032W
Feature Type ORF, Verified
Description Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting (1, 2)
Name Description Beige Protein Homolog 1
Chromosomal Location
ChrIII:179520 to 186023 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All BPH1 GO evidence and references
  View Computational GO annotations for BPH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Large-scale survey
null
Resources
95 total interaction(s) for 89 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 78
  • Phenotypic Enhancement: 1
  • Positive Genetic: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 2,167
Molecular Weight (Da) 250,870
Isoelectric Point (pI) 6.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:179520 to 186023 | ORF Map | GBrowse
This feature contains embedded feature(s): YCRX03C
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..6504 179520..186023 2011-02-03 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000628
References cited on this page View Complete Literature Guide for BPH1
1) Shiflett SL, et al.  (2004) Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting. Traffic 5(9):700-10
2) Perou CM, et al.  (1996) Complementation of the beige mutation in cultured cells by episomally replicating murine yeast artificial chromosomes. Proc Natl Acad Sci U S A 93(12):5905-9