FEN2/YCR028C Summary Help

Standard Name FEN2 1
Systematic Name YCR028C
Feature Type ORF, Verified
Description Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress (2, 3)
Name Description FENpropimorph resistance 1
Chromosomal Location
ChrIII:172424 to 170886 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All FEN2 GO evidence and references
  View Computational GO annotations for FEN2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
41 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • PCA: 6
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 12
  • Positive Genetic: 11
  • Synthetic Lethality: 6
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 512
Molecular Weight (Da) 58,256
Isoelectric Point (pI) 7.2
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:172424 to 170886 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1539 172424..170886 2011-02-03 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000000623
References cited on this page View Complete Literature Guide for FEN2
1) Marcireau C, et al.  (1996) FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast. Yeast 12(6):531-9
2) Stolz J and Sauer N  (1999) The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter. J Biol Chem 274(26):18747-52
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76