MIC10/YCL057C-A Summary Help

Standard Name MIC10 1
Systematic Name YCL057C-A
Alias MIO10 2 , MCS10 3 , MOS1 4
Feature Type ORF, Verified
Description Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; ortholog of human MINOS1 (2, 3, 4, 5)
Name Description MItochondrial contact site and Cristae organizing system 1
Chromosomal Location
ChrIII:24325 to 24032 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MIC10 GO evidence and references
  View Computational GO annotations for MIC10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
69 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 45
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 15
  • Co-fractionation: 1
  • Co-purification: 3

Genetic Interactions
  • Negative Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 97
Molecular Weight (Da) 10,408
Isoelectric Point (pI) 11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:24325 to 24032 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2000-09-14 | Sequence: 2000-09-14
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..294 24325..24032 2000-09-14 2000-09-14
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007547
References cited on this page View Complete Literature Guide for MIC10
1) Pfanner N, et al.  (2014) Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol 204(7):1083-6
2) von der Malsburg K, et al.  (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell 21(4):694-707
3) Harner M, et al.  (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J ()
4) Hoppins S, et al.  (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40
5) Alkhaja AK, et al.  (2012) MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell 23(2):247-57