LRE1/YCL051W Summary

LRE1 BASIC INFORMATION

Standard Name	LRE1
Systematic Name	YCL051W
Feature Type	ORF, Verified
Description	Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes (1, 2)
Name Description	Laminarase REsistance 1

GO Annotations	All LRE1 GO evidence and references
	View Computational GO annotations for LRE1
Molecular Function
Manually curated	protein kinase inhibitor activity (IDA) transcription regulator activity (IDA)
Biological Process
Manually curated	fungal-type cell wall organization (IGI) response to heat (IDA)
Cellular Component
Manually curated	fungal-type cell wall (TAS)

Mutant Phenotype	All LRE1 Phenotype details and references
Classical genetics
overexpression	cell size: increased cellular morphology: abnormal
Large-scale survey
null	viable
overexpression	vegetative growth: decreased

Interactions	LRE1 All interactions details and references
	15 total interaction(s) for 14 unique genes/features.
Physical Interactions	Biochemical Activity: 2 Two-hybrid: 3
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 8 Synthetic Lethality: 1

Sequence Information

ChrIII:35865 to 37616 | |

Last Update

Coordinates: 2000-09-13 | Sequence: 2000-09-13

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1752	35865..37616	2000-09-13	2000-09-13

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000556

LRE1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for LRE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LRE1]

1)	Lai MH, et al. (1997) Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Yeast 13(3):199-213
2)	Versele M and Thevelein JM (2001) Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae. Mol Microbiol 41(6):1311-26

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