LRE1/YCL051W Summary Help

Standard Name LRE1 1
Systematic Name YCL051W
Feature Type ORF, Verified
Description Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Laminarase REsistance 1
Chromosomal Location
ChrIII:35865 to 37616 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LRE1 GO evidence and references
  View Computational GO annotations for LRE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
49 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 3
  • Co-localization: 1
  • PCA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 13
  • Negative Genetic: 10
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 583
Molecular Weight (Da) 64,791
Isoelectric Point (pI) 8.09
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:35865 to 37616 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2000-09-13 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1752 35865..37616 2000-09-13 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000556
References cited on this page View Complete Literature Guide for LRE1
1) Lai MH, et al.  (1997) Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Yeast 13(3):199-213
2) Alonso-Monge R, et al.  (2001) Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects. Mol Microbiol 41(3):717-30
3) Versele M and Thevelein JM  (2001) Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae. Mol Microbiol 41(6):1311-26
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Mancini Lombardi I, et al.  (2013) Lre1 Directly Inhibits the NDR/Lats Kinase Cbk1 at the Cell Division Site in a Phosphorylation-Dependent Manner. Curr Biol 23(18):1736-45