SRO9/YCL037C Summary Help

Standard Name SRO9 1
Systematic Name YCL037C
Feature Type ORF, Verified
Description Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Suppressor of rho3 1
Chromosomal Location
ChrIII:58678 to 57374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SRO9 GO evidence and references
  View Computational GO annotations for SRO9
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Large-scale survey
1039 total interaction(s) for 939 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 63
  • Affinity Capture-RNA: 811
  • Affinity Capture-Western: 14
  • Biochemical Activity: 1
  • PCA: 14

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 5
  • Negative Genetic: 77
  • Positive Genetic: 23
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 10
  • Synthetic Rescue: 6

Expression Summary
Length (a.a.) 434
Molecular Weight (Da) 48,060
Isoelectric Point (pI) 9.7
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIII:58678 to 57374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2003-09-22 | Sequence: 2003-09-22
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1305 58678..57374 2003-09-22 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000542
References cited on this page View Complete Literature Guide for SRO9
1) Kagami M, et al.  (1997) SRO9, a multicopy suppressor of the bud growth defect in the Saccharomyces cerevisiae rho3-deficient cells, shows strong genetic interactions with tropomyosin genes, suggesting its role in organization of the actin cytoskeleton. Genetics 147(3):1003-16
2) Sobel SG and Wolin SL  (1999) Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Mol Biol Cell 10(11):3849-62
3) Hon T, et al.  (2001) The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Mol Cell Biol 21(23):7923-32
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Rother S, et al.  (2010) Nucleocytoplasmic shuttling of the La motif-containing protein Sro9 might link its nuclear and cytoplasmic functions. RNA 16(7):1393-401