Standard Name	BIK1 1
Systematic Name	YCL029C
Alias	ARM5 , PAC14 2
Feature Type	ORF, Verified
Description	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 (3)
Name Description	BIlateral Karyogamy defect 1

Chromosomal Location	ChrIII:69921 to 68599 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -21 cM

	View Computational GO annotations for BIK1
Molecular Function
Manually curated	microtubule binding (IGI) protein homodimerization activity (IDA)
Biological Process
Manually curated	karyogamy involved in conjugation with cellular fusion (IMP) mitotic spindle elongation (IGI) negative regulation of microtubule polymerization (IDA) nuclear migration involved in conjugation with cellular fusion (IMP)
Cellular Component
Manually curated	cell cortex (IDA) condensed nuclear chromosome kinetochore (IDA) kinetochore (IDA) mating projection tip (IDA) microtubule plus end (IDA) spindle (IDA) spindle microtubule (IDA) spindle pole body (IDA)

Classical genetics
conditional	spindle morphology: abnormal
null	chromosome/plasmid maintenance: abnormal resistance to bortezomib: decreased resistance to benomyl: decreased
overexpression	budding index: abnormal cell cycle progression: arrested cell cycle progression in G2 phase: abnormal cell size: increased nuclear morphology: abnormal
reduction of function	chromosome/plasmid maintenance: abnormal mitotic recombination: increased nuclear fusion during mating: absent nuclear position: abnormal
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploproficient heat sensitivity: increased resistance to camptothecin: increased resistance to benomyl: decreased resistance to caffeine: decreased resistance to cycloheximide: increased resistance to ethanol: decreased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	277 total interaction(s) for 152 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 11 Biochemical Activity: 4 Co-fractionation: 1 Co-localization: 2 Co-purification: 1 PCA: 4 Reconstituted Complex: 4 Two-hybrid: 60
Genetic Interactions	Dosage Growth Defect: 3 Negative Genetic: 89 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 7 Synthetic Growth Defect: 21 Synthetic Lethality: 57 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:69921 to 68599 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -21 cM
Last Update	Coordinates: 2000-09-13 | Sequence: 2000-09-13
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1323 69921..68599 2000-09-13 2000-09-13
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000534