FUS1/YCL027W Summary Help

Standard Name FUS1 1
Systematic Name YCL027W
Feature Type ORF, Verified
Description Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate (1, 2, 3, 4)
Name Description cell FUSion 1
Chromosomal Location
ChrIII:71803 to 73341 | ORF Map | GBrowse
Gbrowse
Genetic position: -21 cM
Gene Ontology Annotations All FUS1 GO evidence and references
  View Computational GO annotations for FUS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 12 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
77 total interaction(s) for 51 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-localization: 2
  • PCA: 4
  • Protein-peptide: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 35

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 9
  • Phenotypic Enhancement: 12
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 512
Molecular Weight (Da) 57,779
Isoelectric Point (pI) 9.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:71803 to 73341 | ORF Map | GBrowse
This feature contains embedded feature(s): YCLX07W
SGD ORF map
Genetic position: -21 cM
Last Update Coordinates: 2000-09-13 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1539 71803..73341 2000-09-13 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000532
References cited on this page View Complete Literature Guide for FUS1
1) Trueheart J, et al.  (1987) Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol Cell Biol 7(7):2316-28
2) Bagnat M and Simons K  (2002) Cell surface polarization during yeast mating. Proc Natl Acad Sci U S A 99(22):14183-8
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Nelson B, et al.  (2004) Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating. Genetics 166(1):67-77