FRM2/YCL026C-A Summary Help

Standard Name FRM2 1
Systematic Name YCL026C-A
Alias YCLX08C
Feature Type ORF, Verified
Description Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin (1, 2, 3, 4, 5, 6, 7)
Name Description Fatty acid Repression Mutant 1
Chromosomal Location
ChrIII:75285 to 74704 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All FRM2 GO evidence and references
  View Computational GO annotations for FRM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Regulators 3 genes
Classical genetics
Large-scale survey
11 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 5
  • Phenotypic Enhancement: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 193
Molecular Weight (Da) 21,232
Isoelectric Point (pI) 7.04
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIII:75285 to 74704 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2000-09-13 | Sequence: 2000-09-13
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..582 75285..74704 2000-09-13 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000589
References cited on this page View Complete Literature Guide for FRM2
1) McHale MW, et al.  (1996) Identification of a class of Saccharomyces cerevisiae mutants defective in fatty acid repression of gene transcription and analysis of the frm2 gene. Yeast 12(4):319-31
2) Iwahashi Y, et al.  (2006) Mechanisms of patulin toxicity under conditions that inhibit yeast growth. J Agric Food Chem 54(5):1936-42
3) Azevedo D, et al.  (2007) The S. cerevisiae Yap1 and Yap2 transcription factors share a common cadmium-sensing domain. FEBS Lett 581(2):187-195
4) de Oliveira IM, et al.  (2007) In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. Biochem Biophys Res Commun 355(4):919-25
5) Salin H, et al.  (2008) Structure and properties of transcriptional networks driving selenite stress response in yeasts. BMC Genomics 9:333
6) de Oliveira IM, et al.  (2010) The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae. Yeast 27(2):89-102
7) Bang SY, et al.  (2012) Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae. Biochem Biophys Res Commun 423(4):638-41