KCC4/YCL024W Summary Help

Standard Name KCC4
Systematic Name YCL024W
Feature Type ORF, Verified
Description Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication (1, 2, 3, 4)
Chromosomal Location
ChrIII:79162 to 82275 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KCC4 GO evidence and references
  View Computational GO annotations for KCC4
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
113 total interaction(s) for 85 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-Western: 6
  • Biochemical Activity: 10
  • PCA: 11
  • Reconstituted Complex: 24
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 29
  • Positive Genetic: 5
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,037
Molecular Weight (Da) 116,473
Isoelectric Point (pI) 9.4
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:79162 to 82275 | ORF Map | GBrowse
This feature contains embedded feature(s): YCL022C
SGD ORF map
Last Update Coordinates: 2006-01-12 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3114 79162..82275 2006-01-12 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000529
References cited on this page View Complete Literature Guide for KCC4
1) Barral Y, et al.  (1999) Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev 13(2):176-87
2) Okuzaki D and Nojima H  (2001) Kcc4 associates with septin proteins of Saccharomyces cerevisiae. FEBS Lett 489(2-3):197-201
3) Okuzaki D, et al.  (2003) The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Genes Genet Syst 78(2):113-26
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61