RER1/YCL001W Summary Help

Standard Name RER1 1
Systematic Name YCL001W
Feature Type ORF, Verified
Description Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER (1, 2)
Name Description Retention in the Endoplasmic Reticulum 1
Chromosomal Location
ChrIII:111916 to 112482 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RER1 GO evidence and references
  View Computational GO annotations for RER1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 58 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
260 total interaction(s) for 126 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 4
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 3

Genetic Interactions
  • Negative Genetic: 157
  • Phenotypic Enhancement: 58
  • Phenotypic Suppression: 11
  • Positive Genetic: 12
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 188
Molecular Weight (Da) 22,270
Isoelectric Point (pI) 8.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:111916 to 112482 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..567 111916..112482 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000507
References cited on this page View Complete Literature Guide for RER1
1) Nishikawa S and Nakano A  (1993) Identification of a gene required for membrane protein retention in the early secretory pathway. Proc Natl Acad Sci U S A 90(17):8179-83
2) Sato K, et al.  (1995) Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p. Mol Biol Cell 6(11):1459-77