YCG1/YDR325W Summary Help

Standard Name YCG1 1
Systematic Name YDR325W
Alias TIE1 2 , YCS5 3
Feature Type ORF, Verified
Description Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation (1, 3, 4, 5, 6 and see Summary Paragraph)
Name Description Yeast Cap G 1
Chromosomal Location
ChrIV:1117126 to 1120233 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YCG1 GO evidence and references
  View Computational GO annotations for YCG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 1231 genes
Regulators 68 genes
Resources
Classical genetics
conditional
null
overexpression
Large-scale survey
null
reduction of function
Resources
35 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-Western: 5
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Lethality: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,035
Molecular Weight (Da) 117,850
Isoelectric Point (pI) 4.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1117126 to 1120233 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2002-12-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3108 1117126..1120233 2011-02-03 2002-12-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002733
SUMMARY PARAGRAPH for YCG1

YCG1 encodes a yeast condensin subunit (7, 8, 1). The condensin complex is a complex originally identified in Xenopus egg extracts that is required for chromosome condensation (9, 8, 7). Condensin complexes have been identified in many eukaryotes, including Drosophila, human, and S. pombe; the yeast condensin comprises Ycg1p, Brn1p, Smc2p, Smc4p, and Loc7p (7). Ycg1p corresponds to the XCAP-G subunit of the Xenopus 13S condensin (7, 1). Overexpression of YCG1 can suppress temperature-sensitive mutations in BRN1 in an allele-specific manner (1). Disruption of YCG1 causes changes in the transcriptional response to thiamine (2).

Last updated: 2000-04-20 Contact SGD

References cited on this page View Complete Literature Guide for YCG1
1) Ouspenski II, et al.  (2000) Chromosome condensation factor Brn1p is required for chromatid separation in mitosis. Mol Biol Cell 11(4):1305-13
2) Shiba Y, et al.  (1999) Isolation and characterization of the gene conferring thiamine-inducible expression from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 63(8):1414-9
3) Freeman L, et al.  (2000) The condensin complex governs chromosome condensation and mitotic transmission of rDNA. J Cell Biol 149(4):811-24
4) Lavoie BD, et al.  (2002) In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin. J Cell Biol 156(5):805-15
5) Haeusler RA, et al.  (2008) Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev 22(16):2204-14
6) Hashash N, et al.  (2012) Topoisomerase II- and Condensin-Dependent Breakage of MEC1(ATR)-Sensitive Fragile Sites Occurs Independently of Spindle Tension, Anaphase, or Cytokinesis. PLoS Genet 8(10):e1002978
7) Hirano T  (1999) SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes Dev 13(1):11-9
8) Strunnikov AV and Jessberger R  (1999) Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Eur J Biochem 263(1):6-13
9) Hirano T, et al.  (1997) Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Cell 89(4):511-21