YCG1/YDR325W Summary 
| Standard Name | YCG1 |
|---|---|
| Systematic Name | YDR325W |
| Alias | TIE1 1 , YCS5 2 |
| Feature Type | ORF, Verified |
| Description | Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation (2, 3, 4, 5, 6 and see Summary Paragraph) |
| Name Description | Yeast Cap G 3 |
| Chromosomal Location | |
|---|---|
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Gene Ontology Annotations All YCG1 GO evidence and references
| View Computational GO annotations for YCG1 | |
| Molecular Function | |
| Manually curated |
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| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Mutant phenotypes All YCG1 Phenotype evidence and references
| Classical genetics | |
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| conditional | |
| null | |
| overexpression | |
| Large-scale survey | |
| null | |
| reduction of function | |
| Resources |
interactions All YCG1 Interaction evidence and references
| 34 total interaction(s) for 25 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All YCG1 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 2002-12-17 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000002733 |
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SUMMARY PARAGRAPH for YCG1
YCG1 encodes a yeast condensin subunit (7, 8, 3). The condensin complex is a complex originally identified in Xenopus egg extracts that is required for chromosome condensation (9, 8, 7). Condensin complexes have been identified in many eukaryotes, including Drosophila, human, and S. pombe; the yeast condensin comprises Ycg1p, Brn1p, Smc2p, Smc4p, and Loc7p (7). Ycg1p corresponds to the XCAP-G subunit of the Xenopus 13S condensin (7, 3). Overexpression of YCG1 can suppress temperature-sensitive mutations in BRN1 in an allele-specific manner (3). Disruption of YCG1 causes changes in the transcriptional response to thiamine (1).
Last updated: 2000-04-20 
References cited on this page View Complete Literature Guide for YCG1
| 1) | Shiba Y, et al. (1999) Isolation and characterization of the gene conferring thiamine-inducible expression from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 63(8):1414-9 |
| 2) | Freeman L, et al. (2000) The condensin complex governs chromosome condensation and mitotic transmission of rDNA. J Cell Biol 149(4):811-24 |
| 3) | Ouspenski II, et al. (2000) Chromosome condensation factor Brn1p is required for chromatid separation in mitosis. Mol Biol Cell 11(4):1305-13 |
| 4) | Lavoie BD, et al. (2002) In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin. J Cell Biol 156(5):805-15 |
| 5) | Haeusler RA, et al. (2008) Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev 22(16):2204-14 |
| 6) | Hashash N, et al. (2012) Topoisomerase II- and Condensin-Dependent Breakage of MEC1(ATR)-Sensitive Fragile Sites Occurs Independently of Spindle Tension, Anaphase, or Cytokinesis. PLoS Genet 8(10):e1002978 |
| 7) | Hirano T (1999) SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes Dev 13(1):11-9 |
| 8) | Strunnikov AV and Jessberger R (1999) Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Eur J Biochem 263(1):6-13 |
| 9) | Hirano T, et al. (1997) Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Cell 89(4):511-21 |
