YBT1/YLL048C Summary Help

Standard Name YBT1
Systematic Name YLL048C
Alias BAT1 1
Feature Type ORF, Verified
Description Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication (1, 2, 3)
Name Description Yeast Bile Transporter
Chromosomal Location
ChrXII:46265 to 41280 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All YBT1 GO evidence and references
  View Computational GO annotations for YBT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
44 total interaction(s) for 38 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 3
  • PCA: 14

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,661
Molecular Weight (Da) 189,160
Isoelectric Point (pI) 8.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:46265 to 41280 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4986 46265..41280 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003971
References cited on this page View Complete Literature Guide for YBT1
1) Ortiz DF, et al.  (1997) A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport. J Biol Chem 272(24):15358-65
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Sasser TL, et al.  (2012) The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation. Biochem J 448(3):365-72