Standard Name	APM3
Systematic Name	YBR288C
Alias	YKS6 1
Feature Type	ORF, Verified
Description	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway (2, 3, 4)
Name Description	clathrin Adaptor Protein complex Medium chain

Chromosomal Location	ChrII:779463 to 778012 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for APM3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	Golgi to vacuole transport (IMP) protein targeting to vacuole (IMP)
Cellular Component
Manually curated	AP-3 adaptor complex (IDA)

Classical genetics
null	metal resistance: decreased Vam3p distribution: abnormal alkaline phosphatase distribution: abnormal Sna2p distribution: abnormal alkaline phosphatase modification: decreased viable
Large-scale survey
null	polyphosphate accumulation: abnormal glycogen accumulation: increased inositol excretion: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient Pho8p (ALP) modification: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to PM02734: decreased resistance to neothyonidioside: decreased resistance to 4-chlorophenol: decreased resistance to mefloquine: decreased resistance to BPS: decreased resistance to nickel sulfate: decreased stress resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	190 total interaction(s) for 113 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-Western: 2 PCA: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 124 Phenotypic Enhancement: 2 Positive Genetic: 26 Synthetic Growth Defect: 5 Synthetic Lethality: 7 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:779463 to 778012 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1452 779463..778012 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000492