GDT1/YBR187W Summary Help

Standard Name GDT1 1
Systematic Name YBR187W
Feature Type ORF, Verified
Description Protein of unknown function involved in calcium homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant (1, 2, 3)
Name Description Gcr1 Dependent Translation factor 1
Chromosomal Location
ChrII:602634 to 603476 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GDT1 GO evidence and references
  View Computational GO annotations for GDT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 11 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
22 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 3
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 4
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 280
Molecular Weight (Da) 30,340
Isoelectric Point (pI) 5.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:602634 to 603476 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..843 602634..603476 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000391
References cited on this page View Complete Literature Guide for GDT1
1) Barbara KE, et al.  (2007) The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level. Mol Genet Genomics 277(2):171-88
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Demaegd D, et al.  (2013) Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells. Proc Natl Acad Sci U S A 110(17):6859-64