Standard Name	SPP381 1
Systematic Name	YBR152W
Feature Type	ORF, Verified
Description	mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description	Suppressor of PrP38-1 1

Chromosomal Location	ChrII:546376 to 547251 | ORF Map | GBrowse

	View Computational GO annotations for SPP381
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	generation of catalytic spliceosome for first transesterification step (IGI) mRNA splicing, via spliceosome (IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA) U4/U6 x U5 tri-snRNP complex (IDA)

Classical genetics
null	growth in exponential phase: decreased
Large-scale survey
conditional	colony sectoring: increased heat sensitivity: increased
null	inviable resistance to ethanol: decreased resistance to St. John's Wort extract: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: normal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	111 total interaction(s) for 71 unique genes/features.
Physical Interactions	Affinity Capture-MS: 53 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-purification: 2 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 38 Positive Genetic: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:546376 to 547251 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..876 546376..547251 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000356