PTC4/YBR125C Summary

PTC4 BASIC INFORMATION

Standard Name	PTC4
Systematic Name	YBR125C
Alias	GCT1
Feature Type	ORF, Verified
Description	Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity (1, 2, 3)
Name Description	Phosphatase Two C 1

GO Annotations	All PTC4 GO evidence and references
	View Computational GO annotations for PTC4
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IDA, ISS)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All PTC4 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased viable
overexpression	resistance to rapamycin: decreased

Interactions	PTC4 All interactions details and references
	View additional details at BioGRID
	83 total interaction(s) for 71 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 PCA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 52 Positive Genetic: 5 Synthetic Rescue: 1

Sequence Information

ChrII:488374 to 487193 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1182	488374..487193	2004-07-16	1997-01-28

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000329

PTC4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PTC4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PTC4]

1)	Cheng A, et al. (1999) Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev 13(22):2946-57
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Shitamukai A, et al. (2004) Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae. J Biol Chem 279(5):3651-61

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