AIM3/YBR108W Summary Help

Standard Name AIM3 1
Systematic Name YBR108W
Feature Type ORF, Verified
Description Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss (1, 2, 3, 4)
Name Description Altered Inheritance rate of Mitochondria 1
Chromosomal Location
ChrII:454822 to 457665 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AIM3 GO evidence and references
  View Computational GO annotations for AIM3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Large-scale survey
null
Resources
219 total interaction(s) for 151 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 18
  • Protein-peptide: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 18

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 114
  • Positive Genetic: 50
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 947
Molecular Weight (Da) 103,863
Isoelectric Point (pI) 9.74
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:454822 to 457665 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2844 454822..457665 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000312
References cited on this page View Complete Literature Guide for AIM3
1) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Germann M, et al.  (2005) Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p. J Biol Chem 280(6):4270-8
4) Michelot A, et al.  (2013) Actin filament elongation in Arp2/3-derived networks is controlled by three distinct mechanisms. Dev Cell 24(2):182-95