Standard Name	SIF2 1
Systematic Name	YBR103W
Alias	EMB1 2
Feature Type	ORF, Verified
Description	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus (1, 3, 4)
Name Description	Sir4p-Interacting Factor 3

Chromosomal Location	ChrII:447709 to 449316 | ORF Map | GBrowse

	View Computational GO annotations for SIF2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	histone deacetylation (IDA) negative regulation of chromatin silencing at telomere (IMP, IPI) negative regulation of meiosis (IPI) positive regulation of stress-activated MAPK cascade (IMP) regulation of transcription, DNA-dependent (IMP)
Cellular Component
Manually curated	nucleus (IDA) Set3 complex (IDA)
High-throughput	Rpd3L-Expanded complex (IDA)

Classical genetics
null	chronological lifespan: decreased metal resistance: increased histone H3 modification: increased Slt2p modification: decreased resistance to tunicamycin: decreased resistance to mycophenolic acid: decreased resistance to tellurite: decreased sporulation: increased rate
overexpression	Sir4p distribution: abnormal
unspecified	transposable element transposition: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to lovastatin: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to neothyonidioside: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased sporulation efficiency: increased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	356 total interaction(s) for 213 unique genes/features.
Physical Interactions	Affinity Capture-MS: 56 Affinity Capture-RNA: 2 Affinity Capture-Western: 3 Two-hybrid: 11
Genetic Interactions	Negative Genetic: 173 Phenotypic Enhancement: 11 Phenotypic Suppression: 17 Positive Genetic: 37 Synthetic Growth Defect: 33 Synthetic Lethality: 8 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:447709 to 449316 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1608 447709..449316 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000307