TEC1/YBR083W Summary Help

Standard Name TEC1 1
Systematic Name YBR083W
Alias ROC1 2
Feature Type ORF, Verified
Description Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member (1, 3, 4, 5, 6)
Name Description Transposon Enhancement Control 1
Chromosomal Location
ChrII:409169 to 410629 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TEC1 GO evidence and references
  View Computational GO annotations for TEC1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 165 genes
Regulators 8 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
Resources
131 total interaction(s) for 75 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 18
  • Biochemical Activity: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 12
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 7
  • Negative Genetic: 40
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 13
  • Positive Genetic: 14
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 486
Molecular Weight (Da) 55,157
Isoelectric Point (pI) 7.71
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:409169 to 410629 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1461 409169..410629 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000287
References cited on this page View Complete Literature Guide for TEC1
1) Laloux I, et al.  (1990) TEC1, a gene involved in the activation of Ty1 and Ty1-mediated gene expression in Saccharomyces cerevisiae: cloning and molecular analysis. Mol Cell Biol 10(7):3541-50
2) Dubois E, et al.  (1982) Expression of the ROAM mutations in Saccharomyces cerevisiae: involvement of trans-acting regulatory elements and relation with the Ty1 transcription. EMBO J 1(9):1133-9
3) Kohler T, et al.  (2002) Dual role of the Saccharomyces cerevisiae TEA/ATTS family transcription factor Tec1p in regulation of gene expression and cellular development. Eukaryot Cell 1(5):673-86
4) Zeitlinger J, et al.  (2003) Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell 113(3):395-404
5) Chou S, et al.  (2006) Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae. Mol Cell Biol 26(13):4794-805
6) Bruckner S, et al.  (2011) The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development. Genetics 189(2):479-94
7) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
8) Madhani HD and Fink GR  (1997) Combinatorial control required for the specificity of yeast MAPK signaling. Science 275(5304):1314-7
9) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
10) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87