Standard Name	TEC1 1
Systematic Name	YBR083W
Alias	ROC1 2
Feature Type	ORF, Verified
Description	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member (1, 3, 4, 5, 6)
Name Description	Transposon Enhancement Control 1

Chromosomal Location	ChrII:409169 to 410629 | ORF Map | GBrowse

	View Computational GO annotations for TEC1
Molecular Function
Manually curated	contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA) RNA polymerase II transcription factor recruiting transcription factor activity (IGI, IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	chronological cell aging (IMP) invasive growth in response to glucose limitation (IMP) positive regulation of transcription from RNA polymerase II promoter in response to stress (IDA) positive regulation of transposition, RNA-mediated (IMP) pseudohyphal growth (IDA, IMP)
Cellular Component
Manually curated	nucleus (IDA)

Binding motifs	Predicted TEC1 Binding Site Locations
	ACATTCYY 7 [Search intergenic regions for ACATTCYY] CATTCC 8 [Search intergenic regions for CATTCC] CATTCYY 9 [Search intergenic regions for CATTCYY] RCATTCYB 10 [Search intergenic regions for RCATTCYB]
Regulatory modules	predicted: cellcycle (245)
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	Ty1 RNA accumulation: decreased chronological lifespan: decreased colony appearance: abnormal filamentous growth: absent invasive growth: absent pseudohyphal growth: decreased pseudohyphal growth: absent subcellular morphology: abnormal transposable element transposition: decreased
overexpression	nuclear morphology: abnormal
unspecified	invasive growth: increased pseudohyphal growth: decreased
Large-scale survey
null	competitive fitness: decreased filamentous growth: decreased invasive growth: absent resistance to amitrole: decreased resistance to sirolimus: decreased resistance to cycloheximide: decreased resistance to propolis extract: decreased viable
overexpression	cell cycle progression: abnormal filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	121 total interaction(s) for 71 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Affinity Capture-Western: 13 Biochemical Activity: 2 Protein-RNA: 1 Reconstituted Complex: 10 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 7 Negative Genetic: 40 Phenotypic Enhancement: 6 Phenotypic Suppression: 13 Positive Genetic: 14 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:409169 to 410629 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1461 409169..410629 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000287