Standard Name	TAT1 1
Systematic Name	YBR069C
Alias	TAP1 2 , VAP1
Feature Type	ORF, Verified
Description	Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description	Tyrosine and tryptophan Amino acid Transporter 1

Chromosomal Location	ChrII:378433 to 376574 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TAT1
Molecular Function
Manually curated	amino acid transmembrane transporter activity (IDA) low-affinity tryptophan transmembrane transporter activity (IGI)
Biological Process
Manually curated	amino acid transport (IDA) transmembrane transport (IDA) tryptophan transport (IGI) tyrosine transport (IMP)
Cellular Component
Manually curated	plasma membrane (ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	L-tyrosine accumulation: decreased metal resistance: increased resistance to sphingosine: increased resistance to FK506: increased resistance to 5-fluorotryptophan: increased viable
overexpression	resistance to FTY720: increased resistance to FK506: increased resistance to phytosphingosine: increased
Large-scale survey
null	alkaline pH resistance: decreased cell cycle progression in G1 phase: increased duration competitive fitness: increased competitive fitness: decreased fermentative growth: decreased rate haploproficient resistance to quinine: decreased resistance to CTBT: decreased resistance to dihydromotuporamine C: decreased resistance to doxorubicin: decreased resistance to amiodarone: decreased resistance to mycophenolic acid: decreased resistance to selenomethionine: increased resistance to methyl methanesulfonate: decreased resistance to cycloheximide: decreased resistance to sodium selenide: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to sirolimus: decreased resistance to benzo[a]pyrene: decreased stress resistance: increased toxin resistance: decreased utilization of phosphorus source: decreased viable
overexpression	resistance to isoflurane: increased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	74 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 3 PCA: 17 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 20 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Growth Defect: 4 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:378433 to 376574 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1860 378433..376574 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000000273