TAT1/YBR069C Summary

TAT1 BASIC INFORMATION

Standard Name	TAT1 1
Systematic Name	YBR069C
Alias	TAP1 2 , VAP1
Feature Type	ORF, Verified
Description	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance (1, 2, 3, 4, 5)
Name Description	Tyrosine and tryptophan Amino acid Transporter 1

GO Annotations	All TAT1 GO evidence and references
	View Computational GO annotations for TAT1
Molecular Function
Manually curated	amino acid transmembrane transporter activity (IDA) low-affinity tryptophan transmembrane transporter activity (IGI)
Biological Process
Manually curated	amino acid transport (IDA) transmembrane transport (IDA) tryptophan transport (IGI) tyrosine transport (IMP)
Cellular Component
Manually curated	plasma membrane (ISS)

Mutant Phenotype	All TAT1 Phenotype details and references
Classical genetics
null	L-tyrosine accumulation: decreased metal resistance: increased resistance to 5-fluorotryptophan: increased resistance to FK506: increased viable
overexpression	resistance to FTY720: increased resistance to FK506: increased
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased fermentative growth: decreased rate resistance to rapamycin: decreased resistance to mycophenolic acid: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to amiodarone: decreased resistance to doxorubicin: decreased resistance to selenomethionine: increased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased toxin resistance: decreased utilization of phosphorus source: decreased viable
overexpression	resistance to isoflurane: increased

Interactions	TAT1 All interactions details and references
	41 total interaction(s) for 38 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Two-hybrid: 20
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Synthetic Growth Defect: 1

Sequence Information

ChrII:378430 to 376571 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1860	378430..376571	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000000273

TAT1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TAT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TAT1]

1)	Schmidt A, et al. (1994) Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol Cell Biol 14(10):6597-606
2)	Heitman J, et al. (1993) The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Mol Cell Biol 13(8):5010-9
3)	Regenberg B, et al. (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28
4)	Bajmoczi M, et al. (1998) TAT1 encodes a low-affinity histidine transporter in Saccharomyces cerevisiae. Biochem Biophys Res Commun 243(1):205-9
5)	Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82

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