Standard Name	NRG2 1
Systematic Name	YBR066C
Feature Type	ORF, Verified
Description	Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication (2, 3, 4)
Name Description	Negative Regulator of Glucose-controlled genes 1

Chromosomal Location	ChrII:370699 to 370037 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NRG2
Molecular Function
Manually curated	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	biofilm formation (IGI) negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter (IGI) negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter (IGI) negative regulation of transcription from RNA polymerase II promoter by glucose (IGI, IMP) pseudohyphal growth (IGI)
Cellular Component
Manually curated	nucleus (IDA)

Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	resistance to quinine: increased
Large-scale survey
null	competitive fitness: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	39 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 23 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:370699 to 370037 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..663 370699..370037 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000270