Standard Name	RKM3 1
Systematic Name	YBR030W
Feature Type	ORF, Verified
Description	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description	Ribosomal lysine (K) Methyltransferase 4

Chromosomal Location	ChrII:298292 to 299950 | ORF Map | GBrowse

	View Computational GO annotations for RKM3
Molecular Function
Manually curated	protein-lysine N-methyltransferase activity (IGI, IMP)
Biological Process
Manually curated	peptidyl-lysine monomethylation (IGI, IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	vegetative growth: decreased rate
Large-scale survey
null	competitive fitness: decreased haploproficient resistance to nickel sulfate: decreased resistance to amiodarone: decreased resistance to arsenite(3-): decreased resistance to methyl methanesulfonate: decreased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to amitrole: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	30 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 16 Phenotypic Enhancement: 1 Positive Genetic: 5 Synthetic Growth Defect: 2 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:298292 to 299950 | ORF Map | GBrowse
Last Update	Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1659 298292..299950 2004-07-16 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000234