NTH2/YBR001C Summary Help

Standard Name NTH2
Systematic Name YBR001C
Feature Type ORF, Verified
Description Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication (1, 2 and see Summary Paragraph)
Name Description Neutral TreHalase
Chromosomal Location
ChrII:241283 to 238941 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NTH2 GO evidence and references
  View Computational GO annotations for NTH2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
44 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 22
  • Phenotypic Enhancement: 4
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 780
Molecular Weight (Da) 89,679
Isoelectric Point (pI) 6.44
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:241283 to 238941 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2343 241283..238941 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000205
SUMMARY PARAGRAPH for NTH2

NTH2 is 77% identical to NTH1, which encodes a cytoplasmic neutral trehalase enzyme. Although NTH2 mRNA has been identified by Northern analysis (1), it does not appear to encode significant trehalase activity, or be involved in trehalose catabolism, as an nth2 null mutant exhibits normal levels of both neutral trehalase activity and trehalose (1). An nth2 null mutant does display sensitivity to heat shock, indicating it may be involved in thermotolerance. NTH2 appears to be induced during stationary phase and repressed during exponential growth (1).

Last updated: 2005-08-12 Contact SGD

References cited on this page View Complete Literature Guide for NTH2
1) Nwaka S, et al.  (1995) Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae. J Biol Chem 270(17):10193-8
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61