SUMMARY PARAGRAPH for ATP1
ATP1 encodes the alpha subunit of mitochondrial ATP synthase (1). The ATP synthase complex utilizes proton motive force to generate ATP from ADP and Pi (4). The structure of this enzyme complex is highly conserved among diverse organisms and consists of two major components, soluble F1 and membrane-bound F0, each of which contains many subunits (5). The catalytic core of the enzyme resides in the F1 component and consists of a hexamer of alternating alpha and beta (Atp2p) subunits(6, 7). These three alpha-beta dimers each provide one of ATP synthase's three catalytic sites. Both alpha and beta subunits are thought to contribute to nucleotide binding and catalysis (4).
Although ATP1 is essential for ATP synthase function, it is not essential for life in yeast. Deletion of ATP1, like deletions in many genes necessary for the function or maintenance of mitochondria, leads to a "petite" phenotype that is slow-growing and unable to survive on nonfermentable carbon sources (1).
General ATP synthase structure and function are reviewed in references 4 and 8. For a review that is specific to yeast, see reference 5.
Last updated: 2000-12-28