TEL1/YBL088C Summary Help

Standard Name TEL1 1
Systematic Name YBL088C
Feature Type ORF, Verified
Description Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) (2, 3, 4, 5, 6, 7 and see Summary Paragraph)
Name Description TELomere maintenance 1
Chromosomal Location
ChrII:59382 to 51019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -60 cM
Gene Ontology Annotations All TEL1 GO evidence and references
  View Computational GO annotations for TEL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
conditional
null
overexpression
Large-scale survey
null
Resources
252 total interaction(s) for 137 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-Western: 7
  • Biochemical Activity: 6
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 10
  • Dosage Lethality: 3
  • Dosage Rescue: 6
  • Negative Genetic: 41
  • Phenotypic Enhancement: 71
  • Phenotypic Suppression: 21
  • Positive Genetic: 5
  • Synthetic Growth Defect: 65
  • Synthetic Lethality: 3
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 2,787
Molecular Weight (Da) 321,524
Isoelectric Point (pI) 6.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:59382 to 51019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -60 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..8364 59382..51019 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000184
SUMMARY PARAGRAPH for TEL1

TEL1 was originally identified in a mutant screen to find genes involved in maintaining telomere length (1). It was later shown that Tel1p is a phosphatidylinositol 3-kinase homolog and is related to the human ATM (ataxia telangiectasia mutated) gene (8, 9). However, despite its similarity to phosphatidylinositol 3-kinases, Tel1p has been shown to have protein kinase activity (10). Ataxia-telangiectasia (AT) is an autosomal recessive disorder that causes cerebellar ataxia, telangiectases, immune defects, and a predisposition to cancer; AT cells are hypersensitive to killing by ionizing radiation (OMIM:607585). Tel1p is a member of the PIK-related kinase family that includes Mec1p, Tor1p, and Tor2p and is involved in DNA repair, recombination, and regulation of the cell cycle (11, 12).

Last updated: 2005-05-27 Contact SGD

References cited on this page View Complete Literature Guide for TEL1
1) Lustig AJ and Petes TD  (1986) Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A 83(5):1398-402
2) Ritchie KB and Petes TD  (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-9
3) Craven RJ, et al.  (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161(2):493-507
4) Giannattasio M, et al.  (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002
5) Nakada D, et al.  (2003) The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 31(6):1715-24
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Lo YH, et al.  (2014) Pch2 prevents mec1/tel1-mediated hop1 phosphorylation occurring independently of red1 in budding yeast meiosis. PLoS One 9(1):e85687
8) Greenwell PW, et al.  (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82(5):823-9
9) Morrow DM, et al.  (1995) TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82(5):831-40
10) Mallory JC and Petes TD  (2000) Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc Natl Acad Sci U S A 97(25):13749-54
11) Keith CT and Schreiber SL  (1995) PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270(5233):50-1
12) Jackson SP  (1996) The recognition of DNA damage. Curr Opin Genet Dev 6(1):19-25