PTH2/YBL057C Summary Help

Standard Name PTH2 1
Systematic Name YBL057C
Feature Type ORF, Verified
Description One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1 (1, 2, 3, 4)
Name Description Peptidyl-Trna Hydrolase
Chromosomal Location
ChrII:113427 to 112801 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PTH2 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
55 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-Western: 6
  • Biochemical Activity: 5
  • Co-purification: 1
  • PCA: 5
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 21
  • Positive Genetic: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 208
Molecular Weight (Da) 22,435
Isoelectric Point (pI) 5.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:113427 to 112801 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..627 113427..112801 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000153
References cited on this page View Complete Literature Guide for PTH2
1) Rosas-Sandoval G, et al.  (2002) Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast. Proc Natl Acad Sci U S A 99(26):16707-12
2) Fromant M, et al.  (2003) Peptidyl-tRNA hydrolase from Sulfolobus solfataricus. Nucleic Acids Res 31(12):3227-35
3) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4) Ishii T, et al.  (2006) Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway. EMBO J 25(23):5492-503