ERD2/YBL040C Summary Help

Standard Name ERD2 1, 2
Systematic Name YBL040C
Feature Type ORF, Verified
Description HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins (1, 2, 3, 4)
Name Description Endoplasmic reticulum Retention Defective 5
Chromosomal Location
ChrII:142868 to 142112 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ERD2 GO evidence and references
  View Computational GO annotations for ERD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
repressible
unspecified
Large-scale survey
conditional
null
repressible
Resources
24 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Co-purification: 1
  • PCA: 8

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 6
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 219
Molecular Weight (Da) 25,762
Isoelectric Point (pI) 10.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:142868 to 142112 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..22 142868..142847 2011-02-03 1997-01-28
Intron 23..119 142846..142750 2011-02-03 1997-01-28
CDS 120..757 142749..142112 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000136
References cited on this page View Complete Literature Guide for ERD2
1) Semenza JC, et al.  (1990) ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway. Cell 61(7):1349-57
2) Hardwick KG, et al.  (1990) ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus. EMBO J 9(3):623-30
3) Beh CT and Rose MD  (1995) Two redundant systems maintain levels of resident proteins within the yeast endoplasmic reticulum. Proc Natl Acad Sci U S A 92(21):9820-3
4) Lewis MJ and Pelham HR  (1990) A human homologue of the yeast HDEL receptor. Nature 348(6297):162-3
5) Pelham HR, et al.  (1988) Sorting of soluble ER proteins in yeast. EMBO J 7(6):1757-62