Standard Name	HEK2 1
Systematic Name	YBL032W
Alias	KHD1 2
Feature Type	ORF, Verified
Description	RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K (1, 2, 3)
Name Description	HEterogeneous nuclear rnp K-like gene 1

Chromosomal Location	ChrII:160184 to 161329 | ORF Map | GBrowse

	View Computational GO annotations for HEK2
Molecular Function
Manually curated	mRNA binding (IDA)
Biological Process
Manually curated	intracellular mRNA localization (IMP, IPI) mRNA stabilization (IGI, IMP) telomere maintenance via telomerase (IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) cytoplasmic mRNA processing body (IDA) nuclear chromosome, telomeric region (IDA)

Classical genetics
activation	Ash1p (1-900)-Luc accumulation: decreased
null	MTL1 mRNA accumulation: decreased Ash1p accumulation: increased Mtl1p-TAP accumulation: decreased Ash1p distribution: abnormal
overexpression	MTL1 mRNA accumulation: increased Ash1p-TAP accumulation: decreased Srl1p-TAP accumulation: decreased Mtl1p-TAP accumulation: increased
Large-scale survey
null	competitive fitness: decreased resistance to streptomycin: decreased resistance to cycloheximide: decreased respiratory growth: absent vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	1183 total interaction(s) for 1150 unique genes/features.
Physical Interactions	Affinity Capture-MS: 49 Affinity Capture-RNA: 1092 Biochemical Activity: 4 Protein-RNA: 4 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 5 Negative Genetic: 4 Phenotypic Enhancement: 1 Phenotypic Suppression: 4 Positive Genetic: 5 Synthetic Growth Defect: 10 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:160184 to 161329 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1146 160184..161329 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000128