Standard Name	SHE1 1 (see Nomenclature conflict Note)
Systematic Name	YBL031W
Feature Type	ORF, Verified
Description	Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function (1, 2, 3, 4, 5)
Name Description	Sensitivity to High Expression 1

Chromosomal Location	ChrII:161699 to 162715 | ORF Map | GBrowse

	View Computational GO annotations for SHE1
Molecular Function
Manually curated	microtubule binding (IDA)
Biological Process
Manually curated	mitotic spindle elongation (IMP)
Cellular Component
Manually curated	colocalizes_with astral microtubule (IDA) cellular bud neck (IDA) nuclear microtubule (IDA) spindle (IDA)
High-throughput	microtubule cytoskeleton (IDA)

Classical genetics
null	cytoskeleton morphology: abnormal gamma ray resistance: decreased resistance to bortezomib: decreased spindle morphology: abnormal
overexpression	budding index: decreased budding index: abnormal cell cycle progression in G2 phase: abnormal cell size: increased nuclear morphology: abnormal spindle morphology: abnormal vegetative growth: decreased rate
Large-scale survey
null	competitive fitness: decreased fermentative growth: decreased rate gamma ray resistance: decreased haploinsufficient resistance to propan-1-ol: decreased resistance to glycolaldehyde: decreased resistance to benomyl: decreased resistance to 5-fluorouracil: decreased respiratory growth: absent stress resistance: decreased vegetative growth: abnormal viable
overexpression	cell cycle progression: abnormal vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	84 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 54 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 9 Synthetic Growth Defect: 8 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:161699 to 162715 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1017 161699..162715 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000127