ACH1/YBL015W Summary Help

Standard Name ACH1 1
Systematic Name YBL015W
Feature Type ORF, Verified
Description Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth (2, 3, 4)
Name Description Acetyl CoA Hydrolase 1
Chromosomal Location
ChrII:194122 to 195702 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ACH1 GO evidence and references
  View Computational GO annotations for ACH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 10 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
135 total interaction(s) for 92 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Co-purification: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 112
  • Positive Genetic: 12
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 526
Molecular Weight (Da) 58,711
Isoelectric Point (pI) 6.77
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:194122 to 195702 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1581 194122..195702 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000111
References cited on this page View Complete Literature Guide for ACH1
1) Lee FJ, et al.  (1990) A glucose-repressible gene encodes acetyl-CoA hydrolase from Saccharomyces cerevisiae. J Biol Chem 265(13):7413-8
2) Buu LM, et al.  (2003) Functional characterization and localization of acetyl-CoA hydrolase, Ach1p, in Saccharomyces cerevisiae. J Biol Chem 278(19):17203-9
3) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
4) Fleck CB and Brock M  (2009) Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification. Fungal Genet Biol 46(6-7):473-85